Active Studies

Clinical trials into the therapeutic applications of cannabinoids are ongoing both in Canada and Internationally. This section contains grouped lists of active relevant clinical trials as of Dec 6, 2012.

Accessed at: http://www.clinicaltrials.gov/ct2/results?term=cannabinoids&pg=1

Current clinical trials are grouped by:
cannabinoid employed
disease targeted
receptor imaging

Clinical trials grouped by the cannabinoid employed:

Cannabidiol
Cannabidiol for Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Stem Cell Transplantation Recruiting  Rabin
Safety and Efficacy of Cannabidiol for Grade I/II Acute Graft Versus Host Disease (GVHD) After Allogeneic Stem Cell Transplantation Recruiting  Rabin
The Effects of Cannabidiol and ∆-9-THC in Humans Recruiting  Yale
Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia Recruiting  Yale
A Clinical Trial on the Antipsychotic Properties of Cannabidiol Completed  Cologne
Evaluation of the Antipsychotic Efficacy of Cannabidiol in Acute Schizophrenic Psychosis Completed  Cologne
Cannabis
Chronic Cannabis Users: A Model for Negative Symptoms in Schizophrenia Recruiting  Shalvata
Cannabis for Inflammatory Bowel Disease Recruiting  Meir
Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis Recruiting  NIDA
Vaporization as a Smokeless Cannabis Delivery System Completed  UCSF
Opioid and Cannabinoid Pharmacokinetic Interactions Completed  NIDA
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks Unknown  NIDA
Characterization of the Analgesic Effects of Oral THC and Smoked Marijuana in Non-Treatment Seeking Marijuana Smokers Unknown  NY Psych
Cannabis for Spasticity in Multiple Sclerosis Recruiting  UCDavis
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana Unknown  MUSC
Dronabinol (Marinol)
The Effects of Cannabinoid on Patients With Non-GERD Related Non Cardiac Chest Pain Recruiting  U Iowa
Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor and Sensory Functions in Patients With Irritable Bowel Syndrome (IBS) Completed  Mayo
Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain Unknown Boston
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain Completed Heidelberg
Marinol in Trichotillomania or Obsessive Compulsive Disorder Completed  UMN
Cannabinoid Receptor (CB1) Agonist Treatment in Severe Chronic Anorexia Nervosa Unknown  Odense
Efficacy of Dronabinol for the Treatment of Cervical Dystonia Unknown  Toronto
Endocannabinoids
Novel Immune Markers in Patients With Multiple Sclerosis (NIMMS) Unknown UW
Nabilone (Cesamet)
Effect of Cannabinoids on Spasticity and Neuropathic Pain in Spinal Cord Injured Persons Recruiting  Manitoba
Nabilone for the Treatment of Phantom Limb Pain Completed Manitoba
A Trial Assessing the Effect of Nabilone on Pain and Quality of Life in Patients With Fibromyalgia Completed Manitoba
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia Completed McGill
Randomized Double Blind Cross Over Study for Nabilone in Spasticity in Spinal Cord Injury Persons Completed Manitoba
A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting Terminated Veeda
Efficacy Study of Nabilone in the Treatment of Diabetic Peripheral Neuropathic Pain Unknown Calgary
Use of the Cannabinoid Nabilone for the Promotion of Sleep in Chronic, Non-Malignant Pain Patients Unknown Toronto
Rimonabant
Effect of Rimonabant on Weight Gain and Body Composition in Adults With Prader Willi Syndrome Recruiting  Cornell
Antagonist-Elicited Cannabis Withdrawal Completed  NIDA
Rimonabant to Reduce Alcohol Consumption Completed  NIAAA
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque Completed  AUTH
The Effects of Rimonabant, on Weight and Metabolic Risk Factors Terminated  Maryland
Japanese Study With Rimonabant in Obese Type 2 Diabetic Patients on Diet and Exercise Terminated  Sanofi
Japanese Study With Rimonabant in Obese Type 2 Diabetic Patients With Oral Anti-Diabetic Drug Terminated  Sanofi
Japanese Study of Rimonabant in Obese Patients With Dyslipidemia (VENUS) Terminated  Sanofi
Sativex
Neuroprotection by Cannabinoids in Huntington's Disease Ongoing  GW Pharma
Sativex for Treatment of Chemotherapy Induced Neuropathic Pain Ongoing  CDHA
Cannabinoids in Bipolar Affective Disorder Ongoing UBC
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation Completed NIDA
Study to Evaluate the Effect of Rifampicin, Ketoconazole, and Omeprazole on the Pharmacokinetics of Sativex Completed  GW Pharma
Sativex Thorough QT/QTc Study Completed  GW Pharma
Study to Assess Food Effect on Sativex Bioavailability Completed  GW Pharma
Abuse Potential of Sativex Completed  GW Pharma
Use of Cannabinoids in Patients With Multiple Sclerosis Unknown Rome
Novel / Synthetic Cannabinoids
A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours Recruiting  e-Therapeutics PLC
Cannabinoid Augmentation of Fear Response in Humans Recruiting Yale
GWMD1092 - GW42003 : GW42004 Together Plus Alone in Type II Diabetes Completed GWPharm
Phase 1 Pharmacokinetic Study Of CP-945598 In Patients With NASH Completed  Pfizer
Efficacy and Safety of Surinabant Treatment as an Aid to Smoking Cessation (SURSMOKE) Completed  Sanofi
A Phase Ib/IIa, Double-Blind, Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of S-777469 in Subjects With Atopic Dermatitis Completed  Shionogi
Combination of an Investigational Cannabinoid and Methadone for HIV-Associated Neuropathy Terminated  UW
Efficacy and Safety of AVE1625 as a co-Treatment With Antipsychotic Therapy in Schizophrenia Terminated   Sanofi
THC
Delta-THC in Pain in Dementia Beginning  Radboud
Efficacy Study of Δ9-THC to Treat Chronic Abdominal Pain (Delta-pain) Recruiting  Radboud
The Effects of ∆-9-THC and Naloxone in Humans Recruiting  Yale
The Effects of Cannabidiol and ∆-9-THC in Humans Recruiting Yale
Effects of Delta-9-THC and Iomazenil in Healthy Humans Recruiting Yale
Gamma-Amino Butyric Acid (GABA) Deficits and Vulnerability to Cannabinoid-Induced Psychosis Recruiting Yale
Cannabinoids, Neural Synchrony, and Information Processing Recruiting Yale
Pharmacogenetics of Cannabinoid Response Recruiting Yale
Cannabinoid Receptor Function & Alcoholism Recruiting Yale
Add on Study on delta 9- THC Treatment for Posttraumatic Stress Disorders (PTSD) Ongoing  Hadassah
Effect of Lofexidine and Oral THC on Marijuana Withdrawal and Relapse Completed  NY Psych
Orexigenic Therapy With Delta-9-Tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study Completed Alberta
Characterization of the Analgesic Effects of Oral THC and Smoked Marijuana in Non-Treatment Seeking Marijuana Smokers Unknown  NY Psych

 

Clinical trials grouped by the disease targeted:

Cancer
A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours Recruiting  e-Therapeutics PLC
Sativex for Treatment of Chemotherapy Induced Neuropathic Pain Ongoing  CDHA
Orexigenic Therapy With Delta-9-Tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study Completed Alberta
Opioid and Cannabinoid Pharmacokinetic Interactions Completed  NIDA
A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting Terminated Veeda
Diabetes/Diet
Effect of Rimonabant on Weight Gain and Body Composition in Adults With Prader Willi Syndrome Recruiting  Cornell
GWMD1092 - GW42003 : GW42004 Together Plus Alone in Type II Diabetes Completed GWPharm
Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics Unknown  UdeM
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque Completed  AUTH
The Effects of Rimonabant, on Weight and Metabolic Risk Factors Terminated  Maryland
Japanese Study With Rimonabant in Obese Type 2 Diabetic Patients on Diet and Exercise Terminated  Sanofi
Japanese Study With Rimonabant in Obese Type 2 Diabetic Patients With Oral Anti-Diabetic Drug Terminated  Sanofi
Japanese Study of Rimonabant in Obese Patients With Dyslipidemia (VENUS) Terminated  Sanofi
Fibromyalgia
A Trial Assessing the Effect of Nabilone on Pain and Quality of Life in Patients With Fibromyalgia Completed Manitoba
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia Completed McGill
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain Completed Heidelberg
HIV/AIDS
Combination of an Investigational Cannabinoid and Methadone for HIV-Associated Neuropathy Terminated  UW
Inflammatory Bowel Disease
Cannabis for Inflammatory Bowel Disease Recruiting  Meir
Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor and Sensory Functions in Patients With Irritable Bowel Syndrome (IBS) Completed  Mayo
Multiple Sclerosis
Cannabis for Spasticity in Multiple Sclerosis Recruiting  UCDavis
Use of Cannabinoids in Patients With Multiple Sclerosis Unknown Rome
Novel Immune Markers in Patients With Multiple Sclerosis (NIMMS) Unknown UW
MUltiple Sclerosis and Extract of Cannabis (MUSEC) Study Terminated  IKFE
Pain
Delta-THC in Pain in Dementia Beginning  Radboud
The Effects of Cannabinoid on Patients With Non-GERD Related Non Cardiac Chest Pain Recruiting  U Iowa
Cannabinoid Modulation of Pain Recruiting  Yale
Efficacy Study of Δ9-THC to Treat Chronic Abdominal Pain (Delta-pain) Recruiting  Radboud
Sativex for Treatment of Chemotherapy Induced Neuropathic Pain Recruiting  CDHA
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors Recruiting Texas
Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain Unknown Boston
Nabilone for the Treatment of Phantom Limb Pain Completed Manitoba
Opioid and Cannabinoid Pharmacokinetic Interactions Completed  NIDA
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain Completed Heidelberg
Efficacy Study of Nabilone in the Treatment of Diabetic Peripheral Neuropathic Pain Unknown Calgary
Use of the Cannabinoid Nabilone for the Promotion of Sleep in Chronic, Non-Malignant Pain Patients Unknown Toronto
Efficacy of Dronabinol for the Treatment of Cervical Dystonia Unknown  Toronto
Characterization of the Analgesic Effects of Oral THC and Smoked Marijuana in Non-Treatment Seeking Marijuana Smokers Unknown  NIDA
Atopic Dermatitis
A Phase Ib/IIa, Double-Blind, Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of S-777469 in Subjects With Atopic Dermatitis Completed  Shionogi
Graft Versus Host Disease
Cannabidiol for Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Stem Cell Transplantation Recruiting  Rabin
Safety and Efficacy of Cannabidiol for Grade I/II Acute Graft Versus Host Disease (GVHD) After Allogeneic Stem Cell Transplantation Recruiting  Rabin
Mental Health
Cannabinoid Augmentation of Fear Response in Humans Recruiting Yale
Addiction
Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment (ACCENT) Beginning Medical University of South Carolina
Behavioral Effects of Tiagabine and Cannabis Recruiting U Kentucky
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence Recruiting NIMH
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation Completed NIDA
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana Unknown  MUSC
Cannabinoid Receptor Function & Alcoholism Recruiting Yale
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal Recruiting Yale
Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia (DCCS) Recruiting Mclean Hospital
Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis Recruiting  NIDA
Exercise as a Treatment for Substance Use Disorders Protocol Ongoing  U Texas SW Medical Center
Dual Diagnosis (Psychosis and Cannabismisuse): Comparison of Specialized Treatment Versus Unspecified Treatment Completed Konstanz
Effect of Lofexidine and Oral THC on Marijuana Withdrawal and Relapse Completed  NYPsych
Antagonist-Elicited Cannabis Withdrawal Completed  NIDA
Rimonabant to Reduce Alcohol Consumption Completed  NIAAA
Efficacy and Safety of Surinabant Treatment as an Aid to Smoking Cessation (SURSMOKE) Completed  Sanofi
Abuse Potential of Sativex Completed  GW Pharma
Anorexia Nervosa
Cannabinoid Receptor (CB1) Agonist Treatment in Severe Chronic Anorexia Nervosa Unknown  Odense
Anxiety Disorders
Add on Study on delta 9- THC Treatment for Posttraumatic Stress Disorders (PTSD) Ongoing  Hadassah
Marinol in Trichotillomania or Obsessive Compulsive Disorder Completed  UMN
Cannabinoids in Bipolar Affective Disorder Ongoing UBC
Schizophrenia / Psychosis
Chronic Cannabis Users: A Model for Negative Symptoms in Schizophrenia Recruiting  Shalvata
Gamma-Amino Butyric Acid (GABA) Deficits and Vulnerability to Cannabinoid-Induced Psychosis Recruiting Yale
Cannabinoids, Neural Synchrony, and Information Processing Recruiting Yale
Imaging Cannabinoid CB1 Receptors in Schizophrenia Recruiting NIMH
Effects of Delta-9-THC and Iomazenil in Healthy Humans Recruiting Yale
The Effects of Cannabidiol and ∆-9-THC in Humans Recruiting  Yale
Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia Recruiting  Yale
A Clinical Trial on the Antipsychotic Properties of Cannabidiol Completed  Cologne
Evaluation of the Antipsychotic Efficacy of Cannabidiol in Acute Schizophrenic Psychosis Completed  Cologne
Dual Diagnosis (Psychosis and Cannabismisuse): Comparison of Specialized Treatment Versus Unspecified Treatment Completed Konstanz
Niacin Flushing as Marker of Cannabis Effects on Arachidonic Acid Pathways in Schizophrenia Completed Jena
Efficacy and Safety of AVE1625 as a co-Treatment With Antipsychotic Therapy in Schizophrenia Terminated   Sanofi
Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics Unknown  UdeM

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